The ages old debate. N-Acetyl-L-Tyrosine VS L-Tyrosine. Well, maybe not age old. But debate worthy for sure. I’ve taken L-Tyrosine for about 8 years, on and off, and I love the stuff.
Tyrosine is a precursor to thyroid hormones, and a few nifty neuro-chemicals (Dopamine, Epinephrine, Norepinephrine).
It’s incredibly stimulating, stacks well with caffeine, L-theanine, Selenium, Iodine, and some cholinergic compounds, and seems sustainable to take in low doses with appropriate co-factors (particularly Iodine and Selenium).
But there is another form of L-Tyrosine, that the nootropics community likes to discuss. Some people swear by it, actually. And it’s the acetylated version of L-Tyrosine, N-acetyl-l-tyrosine.
NALT, for short, is technically a step closer in the metabolism process of L-Tyrosine, by adding acetic acid to L-Tyrosine, forming “N-acetyl-l-tyrosine. It’s suppose to make L-Tyrosine more “bioavailable.”
And perhaps it does. But the real question is: is it more useful to take NALT over L-Tyrosine? And my personal answer to that question is: no. Here are the details:
- NALT, IS in fact effective at inducing stimulatory effects in my brain, and a lot of other people’s brains. But, my own personal experience is that it doesn’t seem to last as long, and be as sustainable and strong as regular L-Tyrosine. This study demonstrates that NALT is excreted via urine at a relatively high rate. Perhaps this means that the bioavailability of NALT = faster and higher excretion of NALT? Maybe. And maybe this means that it doesn’t last as long, in terms of effects, which would match my anecdotal experience.
- This doesn’t immediately mean that NALT is definitively less effective than regular L-Tyrosine. It means that lots of NALT is excreted via Urine, and blood levels of NALT, though increased, do not remain considerably high.
- Some people have taken this to mean that NALT is not as powerful as Tyrosine, and that’s not what this means. It merely means: NALT does not have an advantage over L-Tyrosine.
And that’s the major takeaway. There is no biological advantage, it seems, in taking NALT over L-Tyrosine. NALT itself does in fact create a stimulatory response in most people, me included, but my own personal experience tells me that L-Tyrosine is more stable, lasts longer, and is just as effective, in terms of onset.
Therefore: I am concluding, as I do in the video below, that NALT is not more effective than L-Tyrosine, and you’re better off just using L-Tyrosine. L-Tyrosine by itself is considerably strong, onsets quick, and lasts long. For more information on the granular chemical details of N-Acetyl-L-Tyrosine, head over to Pubchem’s page on it, here.
Enjoy the video!