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Why do you have to take a choline source with a Racetam? That question is the topic of the latest Cortex Nootropics Podcast episode.

In this episode, we’ll discuss: 

1. Why most people require a choline source when taking racetams.
2. The mechanism behind acetylcholine depletion in the presence of racetams.
3. How the usage of acetylcholine in the hippocampus induced by certain racetams might underlie the improved memory performance some users report.
4. Low dosing on Racetams.
5. Carefully experimenting with choline sources to find the best type and quantity that works best for you with specific racetam doses.
6. A rat study that demonstrated a 63% usage and release of acetylcholine in the hippocampus, in the presence of Oxiracetam and Aniracetam.

Links mentioned/referenced:

1. Oxiracetam and aniracetam increase acetylcholine release from the rat hippocampus in vivo.
2. Profound effects of combining choline and piracetam on memory enhancement and cholinergic function in aged rats.
3. The Nootropics subreddit I mentioned with Oakfad’s user experience.
4. The Cortex Nootropic Stacks.