My Experience With Sulbutiamine – The Motivation Nootropic

synapses_mental_integrationSulbutiamine, which chemically is a synthetic derivative of vitamin B1 (Thiamine), is quite the interesting nootropic. Upon trying it, I had a bit of history from reading about the substance on the internet.

I was kind of blown away. People reported feeling surges of motivation from the substance. As if it had somehow increased the dopamine production in their brains. Does Sulbutiamine increase dopamine production? I mean.. the Wikipedia page states that: “Several studies have shown that sulbutiamine improves memory through the potentiation of cholinergic, dopaminergic, and glutamatergic transmission.” It could be quite possible.

Read more of the Wikipedia page on Sulbutiamine here. 

Anyway, let’s talk a bit about motivation, and the dopamine pathway.

Motivation is like exercising; it doesn’t last forever, and if you over consume above your caloric maintenance level, you have to exercise again to burn calories to put you back at maintenance, or a deficit if you’re trying to kill body fat.

You have to constantly reinforce your motivation to get it going. For me, one of the best ways to do that is to literally sit and envision what I want for my life. But that’s not all. Things in my current life have to be working at some level for motivation to thrive as well. Progress is happiness.

According to this article, the most important reward pathway in the brain is the “mesolimbic dopamine system.” Called the VTA NAc pathway, (directly from the article here): The VTA is the site of dopaminergic neurons, which tell the organism whether an environmental stimulus (natural reward, drug of abuse, stress) is rewarding or aversive.

Is this pathway somehow enhanced from Sulbutiamine usage? From this Pubmed abstract: In the same treated animals, an increase of D1 dopaminergic (DA) binding sites was measured both in the prefrontal and the cingular cortex, while no modification of the D2 binding sites was detected (after Sulbutiamine usage).

There are even talks of a “Sulbutiamine Euphoria,” found here in this Reddit thread titled as such.

The above seem to be a good combination of anecdotal and scientific evidence to support the motivation enhancing qualities of this substance.

My experience

One word: Drive. I was fully automated and in one gear: GO. All my desire to work was back. My ability to execute was at an all time high. It was like I finally understood again (after a long stint of drained motivation) what it felt like to be driven like a madman to get my stuff done. I was hooked. It made me realize that I shouldn’t SKIMP on meditation throughout the day, because meditation always makes me feel driven. It reinforced the ONE idea that I tell everyone, that I truly believe is true: When the brain’s reward and functioning systems are at their peak, there isn’t much that can stop you.

Thereafter, I didn’t take the supplement for quite some time. I was interested in reproducing that same effect in my brain, without the supplement. Did I just need more Thiamine? Had I not been visualizing enough? Not meditating enough? All interesting questions to ask, and a worthwhile goal to strive toward: the goal of creating an insane level of motivation naturally. But hey – sometimes you just need more Vitamin B1.

Almost made it to Cortex

It’s funny – because this ingredient ALMOST made it into the first Generation of the Cortex Nootropic. But.. it didn’t. For reasons unknown, Sulbutiamine just didn’t jive too well with the other ingredients of the stack. There has to be some type of pathway conflict that takes place here, or perhaps a competition of nutrients on their way to the blood brain barrier.

I really wanted to make it a part of the stack. It’s such a great new nootropic with a lot of promise, and for that extra wow effect, I wanted to be able to say Sulbutiamine was in the stack. But – when it comes to efficacy, if an ingredient doesn’t play well with the other boys and girls, it can’t be in the stack. Fine with me. But rest assured! I will try to incorporate the stack into future generations and types of Cortex. There will be a Gen 2, Gen 3, Gen 4, and so on, and each of them will have their own purposes. Ex: Fluidity, Focus, Motivation, etc.

How to get started with this nootropic?

Frankly, I’d grab a bag of bulk powder from Powder City (that’s where I purchased mine), and have at it. I’d get some: 00 size capsules, a small cheap capsule maker from Amazon, a $25.00 milligram scale, and go to town. The dosages will range based on multitudes of variants that have to do with your physiology. Mainly: Your gut functionality (digesting and assimilating the nutrient), how much sleep you’ve gotten in the last 48 hours, your blood sugar functionality at the time of dosage, and the proximity of ingestion to food. But I stick with 100-200MG doses.

My personal suggestion is to take the nutrient at least 40 minutes after you’ve eaten. Most nootropics do best when quick absorption can take place, rather than a distorted attempt to absorb the substance takes place because your stomach is filled with the oatmeal you just ate.

A final note on motivation

Motivation is the root to your plant. It’s the foundation to the house. The seed that sprouts the tree. It’s everything. Inducing a state of motivation is among one of the hardest things to do for most people, especially if you’re experiencing some type of all time low in your life. Life is difficult. It does not go the way you want it to go. Man. It not only doesn’t go how you want it to go, it deliberately tries to go the opposite way. Fighting uphill and trying to win in the realm of motivation, happiness, and getting your life to move in the direction you want it to move is like scratching and clawing your way through a never ending river of Marsh.

It’s hard. But it can be done, and you can overcome your motivation shortcomings, if you have them. Progress in your life’s goals really really helps. Meditating twice a day for 30 minutes at a time also really helps. Stopping thinking, and starting acting helps tremendously too. And lastly, conditioning the brain. I look up to Ronda Rousey, the MMA superstar and undefeated women’s Bantamweight champion of the world, because she talks about conditioning. Conditioning the mind.

Train your brain to believe you’ll succeed. Train your brain to believe you’re going to make it. Exist in a special world where you’re the most motivated, forward moving, kick ass person in the world, and it’ll help you on the outside.

But if all else fails, and your brain needs that extra chemical surge, Sulbutiamine is quite the awesome nootropic for just that. I’d recommend it to anyone, any day.

And PS: I will really try to get this substance in future generations of Cortex! I just have to find the right combination of nutrients to pair it with that create a synergistic outcome. Then boom, it’s on.

Sources and referential data

1. Sulbutiamine Wikipedia Page – Wikipedia

2. Brain reward pathways – Icahn school of medicine, Nester Lab, Laboratory of molecular psychiatry.

3. Evidence for a modulatory effect of sulbutiamine on glutamatergic and dopaminergic cortical transmissions in the rat brain. Key-Obs S.A., Centre d’Innovation, 16, rue Leonard de Vinci, 45074 Orleans, 2, Cedex, France.

4. Extreme sulbutiamine euphoria – Reddit Thread

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